SIE Seminar: Zhuo Chen
Thursday, February 22, 2024 - 2:00 p.m.
Zhuo Chen
PhD Candidate
Statistics and Data Science Graduate Interdisciplinary Program
University of Arizona
"Statistical Reconstruction for Positronium Lifetime Imaging"
ENGR 301
Abstract:
Positronium lifetime imaging (PLI) is a medical imaging technique that measures the lifespan of positronium between its emission and annihilation, which provides crucial information for tumors diagnosis. To address the challenge of reconstructing these images with limited resolution in time measurements, we developed a maximum likelihood algorithm and demonstrated its capability to generate quantitatively accurate lifetime images for a system with a relatively low time resolution. We further investigated the statistical properties of the algorithm, including the variability of the reconstruction results, the sensitivity of the algorithm to the number of acquired PLI events, and its robustness to hyperparameter choices. In addition, we examined the potential extension of the proposed algorithm to a two-component decay model, incorporating the annihilation processes of both ortho-positronium and para-positronium.
Bio:
Zhuo Chen is a PhD candidate in statistics at the University of Arizona. His research focuses on statistical reconstruction for medical imaging data, multimodal data integration and single-cell RNA sequencing data analysis. He received his master’s degree in statistics from the University of Minnesota Duluth.