Designing a system for a space mission (e.g. spacecraft, smallsat, cubesat) is a complex endeavor that requires the understanding of a variety of specialized subjects: orbital mechanics, attitude determination and control, space communications, thermal control, propulsion, power systems, structure and mechanisms. The course structure is conceived to provide the students with the skills and methodologies required to complete a preliminary design of a space system at both system and subsystem levels. Fundamentals of spacecraft subsystem design are introduced and embedded in a model-based system engineering process that will drive the preliminary design of a full-scale space system. The lectures will provide the technical content that drives the system and subsystem design that will be accomplished throughout the semester.